What question did this study set out to answer?

This research focuses on developing a photocatalytic method for constructing sulfonamide scaffolds via difluoromethylation and aminosulfonylation of alkenes.

March 14, 2026Green Synthesis and CatalysisOpen Access

Photocatalytic 1,2-difluoromethylation/aminosulfonylation of unactivated alkenes: access to β-difluoromethylated sulfonamides

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Authors

YDYing DongNortheast Normal University YGYunliang GuoNortheast Normal University KJKehan JiaoNortheast Normal University

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Research reveals photocatalytic difluoromethylation and aminosulfonylation of alkenes, suggesting efficient sulfonamide production.

Key Points

This research focuses on developing a photocatalytic method for constructing sulfonamide scaffolds via difluoromethylation and aminosulfonylation of alkenes.
Utilized commercially available CF2HSO2Na as a bifunctional reagent.
Employed O-Ts hydroxylamine for electrophilic amination.
Investigated the reaction mechanism, highlighting radical-polar crossover processes.
Demonstrated broad substrate scope for unactivated alkenes.
Achieved high functional group tolerance in late-stage functionalization.
Provided an environmentally friendly strategy for synthesizing β-difluoromethylated sulfonamides.

Cite This Study

Dong et al. (2026) studied this question.

synapsesocial.com/papers/69b4ba3618185d8a398030da https://doi.org/10.1016/j.gresc.2026.03.006

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Photocatalytic 1,2-difluoromethylation/aminosulfonylation of unactivated alkenes: access to β-difluoromethylated sulfonamides

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Key Points

Cite This Study

Photocatalytic 1,2-difluoromethylation/aminosulfonylation of unactivated alkenes: access to β-difluoromethylated sulfonamides

Discussion

Member takes

Implication

Key Points

Cite This Study

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