Cohort (n=2,071)
No
Unsupervised clustering of routine echocardiographic data in sepsis patients identified five distinct cardiac phenotypes, revealing that right ventricular dilation with elevated tricuspid regurgitation gradient is associated with the highest risk of in-hospital mortality.
May warrant closer monitoring for RV dilation in sepsis; extends phenotyping via echo clustering for mortality risk stratification.
Using an unsupervised clustering analysis, we identified five phenotypes of cardiac function in sepsis based on commonly recorded echocardiographic data: diastolic dysfunction, left ventricular systolic dysfunction with low cardiac index, right ventricular dilation with elevated tricuspid regurgitation gradient, hyperdynamic cardiac function, and normal. The right ventricular dilation group had the highest mortality. Future research should explore mechanisms and potential treatment implications for these groups.
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Shvilkina et al. (2026) conducted a cohort in sepsis (n=2,071).
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