What question did this study set out to answer?

This review aims to synthesize insights from animal models on how Foxp2 mutations affect brain and gastrointestinal development relevant to ASD and SLD.

March 14, 2026Frontiers in NeuroanatomyOpen Access

Foxp2 mutations and abnormal brain and gastrointestinal development: insights from animal models of speech-language and autism spectrum disorders

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Authors

EFEriko Fujita-JimboJichi Medical University GKG. KawaharaTokyo Medical University TMTakashi MomoiTokyo Medical University

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Implication

This review explores the effects of Foxp2 mutations on brain and gut development in animal models, highlighting implications for neurodevelopmental disorders.

Key Points

This review aims to synthesize insights from animal models on how Foxp2 mutations affect brain and gastrointestinal development relevant to ASD and SLD.
Analysis of animal models with Foxp2 mutations
Discussion of brain structures like cerebral cortex and thalamus
Examination of gastrointestinal features in mutants
Investigation of gene-editing approaches using zebrafish and Drosophila
Heterozygous Foxp2 mutants show communication deficits and brain malformations.
Homozygous mutants exhibit severe phenotypes, including early lethality and profound vocalization deficits.
Gastrointestinal abnormalities linked to disrupted Wnt signaling and autoregulation,
Findings underscore the brain-gut-microbiome connection in neurodevelopmental issues.

Cite This Study

Fujita-Jimbo et al. (2026) studied this question.

synapsesocial.com/papers/69b4fa9ab39f7826a300b502 https://doi.org/10.3389/fnana.2026.1783101

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Implication

This review explores the effects of Foxp2 mutations on brain and gut development in animal models, highlighting implications for neurodevelopmental disorders.

Foxp2 mutations and abnormal brain and gastrointestinal development: insights from animal models of speech-language and autism spectrum disorders

Discussion

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Implication

Key Points

Cite This Study

Foxp2 mutations and abnormal brain and gastrointestinal development: insights from animal models of speech-language and autism spectrum disorders

Discussion

Member takes

Implication

Key Points

Cite This Study

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