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Retrospective cohort study reveals no increased risk of fetal malformations after methotrexate treatment for ectopic pregnancy, suggesting safety during early conception.
Conception 1-3 and 3-6 months after methotrexate treatment for ectopic pregnancy does not appear to increase the risk of major fetal malformations, or other unfavorable obstetric outcomes. Prospective studies in larger cohorts are warranted.
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Rosh et al. (2026) studied this question.
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