Retrospective cohort study reveals a 72.8% success rate for single-dose methotrexate in ectopic pregnancy, indicating higher failure with high baseline beta-hCG and fetal cardiac activity.
OBJECTIVE: To evaluate the success of systemic single-dose methotrexate (MTX) treatment in patients with ectopic pregnancy (EP) and to investigate factors related to treatment success. METHODS: failure). RESULTS: = 0.004). Treatment success was not affected by past history of ectopic pregnancy, thickness of endometrium, progesterone value or presences of pseudosac and free pelvic fluid. CONCLUSION: The success rate of single dose MTX in this study was 72.8 %, and we found that failure rate of MTX treatment was 8.45 times more in group of patients whose initial serum β-hCG values were above 2678 IU/L and 12 times more in patients with fetal cardiac activity.
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