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The aim is to present a rare case of synchronous triple primary malignancies and emphasize diagnostic importance.

Synchronous triple cancers of synchronous endometrial and ovarian carcinoma complicated by renal cancer: a case report

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The aim is to present a rare case of synchronous triple primary malignancies and emphasize diagnostic importance.
Reported a 60-year-old female with synchronous endometrial and ovarian carcinoma.
Underwent comprehensive staging surgery and molecular subtyping.
Conducted whole-abdomen MRI revealing a renal mass.
Performed germline genetic testing to rule out hereditary syndromes.
Diagnosed with primary carcinomas of endometrium, ovary, and kidney.
Pathology confirmed papillary renal cell carcinoma.
No recurrence or metastasis observed during 12-month follow-up.
Molecular testing indicated mismatch repair deficiency without indicating Lynch syndrome.

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Case report reveals synchronous triple malignancies, highlighting diagnostic challenges and treatment implications.

Xu et al. (2026) studied this question.

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