What is the clinical evidence from this study?

Study design: Case Report. Population: Scrub typhus (n=1). Intervention: Doxycycline and Azithromycin. Primary outcome: Concurrent splenic and renal infarction.

What does this research mean for the field?

Concurrent splenic and renal infarction can occur in patients with scrub typhus due to disseminated vasculitic and microangiopathic injury. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.CHALLENGES_CONSENSUS.

What question did this study set out to answer?

To highlight rare cases of concurrent splenic and renal infarction associated with scrub typhus infection.

March 14, 2026BMC Infectious DiseasesOpen Access

Concurrent splenic and renal infarction in scrub typhus: expanding the vasculitic spectrum

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Key result

Scrub typhus linked to concurrent splenic and renal infarction driven by visceral ischemia.

Why the study?

While systemic vasculitis and multiorgan dysfunction are well recognized in scrub typhus, ischemic infarction of solid organs is distinctly uncommon.

Population

A 35-year-old previously healthy woman with scrub typhus

Design

Case report

Authors

YNYallawar Nipun NarayanInstitute of Medical Sciences and Sum Hospital SPSagarika PandaInstitute of Medical Sciences and Sum Hospital BNBiswajit NayakInstitute of Medical Sciences and Sum Hospital

Discussion

Member takes

Implication

Consider visceral ischemia in scrub typhus with persistent abdominal pain; challenges consensus that solid organ infarction is uncommon.

Key Points

To highlight rare cases of concurrent splenic and renal infarction associated with scrub typhus infection.
Presented a case study of a previously healthy woman with symptoms of scrub typhus.
Performed laboratory evaluations including IgM enzyme-linked immunosorbent assay and imaging studies.
Administered intravenous doxycycline and azithromycin treatment.
Identified splenic and renal infarctions via contrast-enhanced computed tomography.
Exclusion of other potential embolic sources and conditions causing ischemia.
Achieved rapid clinical improvement and complete recovery following treatment.

Study Design

Type

Case Report (n=1)

Multicenter

Structured PICO

Population

1 previously healthy 35-year-old woman with scrub typhus presenting with acute febrile illness, respiratory symptoms, and left upper-quadrant abdominal pain.

Intervention

Intravenous doxycycline (100 mg twice daily) and azithromycin (500 mg once daily)

Outcome

Clinical recovery and hospital discharge

Scrub typhus can cause concurrent splenic and renal infarction due to disseminated vasculitis, highlighting the need to consider visceral ischemia in patients with persistent abdominal pain.

Limitations

Single case report with no statistical analysis, limiting generalizability.

Cite This Study

Narayan et al. (2026) conducted a case report in Scrub typhus (n=1). Doxycycline and Azithromycin was evaluated on Concurrent splenic and renal infarction. Concurrent splenic and renal infarction occurred in a 35-year-old woman with scrub typhus, highlighting the disease's potential for causing visceral ischemia.

synapsesocial.com/papers/69b4fb1bb39f7826a300b9fa https://doi.org/10.1186/s12879-026-13019-w

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Concurrent splenic and renal infarction in scrub typhus: expanding the vasculitic spectrum

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Limitations

Cite This Study

Concurrent splenic and renal infarction in scrub typhus: expanding the vasculitic spectrum

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Limitations

Cite This Study

Also Consider

Also Consider