Multi-omics study uncovers immune escape mechanisms in bladder cancer, highlighting the role of the CXCL5-CXCR2 axis.
The CXCL5-CXCR2 axis mediates bladder cancer cell-macrophage crosstalk: macrophages promote tumor growth, immune escape, and cisplatin tolerance; tumor cells induce macrophage polarization and reshape immunosuppressive TME. Additionally, this axis drives bladder cancer malignant progression and enhances immunotherapy efficacy.
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Jiang et al. (2026) studied this question.
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