Case report shows sustained improvement in suicidality after lamotrigine augmentation in treatment-resistant depression, suggesting new treatment options.
Key Points
To describe the effects of lamotrigine augmentation on suicidality in a patient with treatment-resistant depression.
Case report of a 58-year-old male with treatment-resistant depression and chronic suicidality.
Lamotrigine was combined with duloxetine, a serotonin-norepinephrine reuptake inhibitor.
Clinical changes in depression and suicidality were monitored after lamotrigine initiation.
The patient showed a brief improvement in depression symptoms.
There was a sustained improvement in suicidality for 2 years.