This research demonstrates Wnt inhibitory factor 1's role in regulating macrophage polarization, suggesting therapeutic potential for diabetic retinopathy.
Overexpression of WIF1 inhibits glycolysis via the HIF1α/PFKFB3 signalling pathway, thereby modulating the polarization of macrophages and alleviating the progression of DR. These findings suggest that WIF1 could be a promising therapeutic target for DR.
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Wang et al. (2026) studied this question.
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