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March 14, 2026International Journal of SurgeryOpen Access

Comment on “Deciphering pathogenic mechanisms of BDCPP exposure in endometrial cancer progression via an integrated approach combining network toxicology, machine learning, and molecular docking”

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Authors

YGYiming GaoQZQin ZhangLirong GaoMinghui ZhengMLMulin Liu

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Overview

Observational comment identifies BDCPP as an environmental driver of endometrial cancer progression, suggesting future research directions.

Key Points

  • The aim is to explore how BDCPP exposure contributes to endometrial cancer progression and its implications for surgical practice.
  • Review of recent findings by Wang et al.
  • Discussion of multi-omics approaches used in the study.
  • Analysis of BDCPP's role in ER signaling and cancer progression.
  • Assessment of the need for personalized treatment based on BDCPP exposure.
  • Identification of ESR1 and VEGFA as key molecules in BDCPP-related malignancy.
  • Proposes a link between BDCPP levels and increased surgical risks after hysterectomy.
  • Suggests potential personalized treatment adjustments for patients with high BDCPP exposure.

Cite This Study

Gao et al. (2026) studied this question.

synapsesocial.com/papers/69b4fbd5b39f7826a300c58dhttps://doi.org/10.1097/js9.0000000000005056
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Integrated network toxicology suggests potential mechanisms involving environmental flame retardant TDCPP in ovarian cancer progression via “liver-to-ovary crosstalk.”2026
  2. 2Comment on “Elucidating the molecular mechanisms of perfluorodecanoic acid and perfluorooctane sulfonic acid on glioblastoma through network toxicology and bioinformatics”2026
  3. 3Mechanistic insights into endocrine-disrupting chemicals in endometriosis and polycystic ovary syndrome: integrating network toxicology and molecular dynamics2025
  4. 4Integrative network toxicology and experimental evidence reveal mechanisms underlying diethyl phthalate-induced initiation and progression of endometrial cancer2026
  5. 5Investigating the Shared Mechanisms of Endocrine-Disrupting Chemicals in Urogenital Tumors2026