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March 14, 2026CNS & Neurological Disorders - Drug Targets

Cyclodextrins-Phospholipids Complex Loaded Nanofibers for Improved Oral Bioavailability and Brain Targeting for Management of Stress andAnxiety

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Authors

IZIqra ZaiNHNazeer HasanMAMohd Aqil

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Overview

Demonstrates enhanced brain uptake and therapeutic efficacy in managing anxiety and depression, indicating a new drug delivery method.

Key Points

  • The study aims to develop a drug delivery system that enhances drug solubility, permeability, and targeted release for stress and anxiety management.
  • Developed a cyclodextrin-phospholipid inclusion complex for drug encapsulation.
  • Utilized electrospinning to create a nanofiber matrix.
  • Evaluated the solubility and release profile of the drug-loaded nanofibers.
  • Assessed the drug's brain uptake in preclinical models.
  • Improved drug solubility and membrane permeability were observed.
  • Nanofibers exhibited a high surface area allowing increased drug loading.
  • Sustained release of drugs potentially reduces dosing frequency.
  • Enhanced drug delivery can lead to better patient compliance.

Cite This Study

Zai et al. (2026) studied this question.

synapsesocial.com/papers/69b4fbeab39f7826a300c77ehttps://doi.org/10.2174/0118715273411008251202124600
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Tailoring nanoplatforms for depression applications2026
  2. 2Amelioration of Anxiety Disorders Using Nanotechnology-Based Drug Delivery Systems2026
  3. 3Harnessing Nanocarriers to Improve Psychiatric Treatment: Progress, Limitations, and Future Directions2026
  4. 4Fabrication and Characterization of Amisulpride Nanofibers for Enhanced Oral Pharmacodynamic Properties2025
  5. 5Cross-linked Chitosan-Based Shell with Mirtazapine Lipid Polymer Hybrid Core as Integrated Spray-Dried Bionanocomposites for Boosted Brain-Directed Oral Delivery2025