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March 14, 2026Microbiology SpectrumOpen Access

Mapping the geodispersal and evolutionary dynamics of regional Nipah virus strain in Bangladesh

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Authors

MRMd Mahfuzur RahmanUniversity of Science and TechnologySRShahreen RahmanInternational Centre for Diarrhoeal Disease ResearchSRSamiur RahimUniversity of Dhaka

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Implication

Analyzes the geodispersal and phylodynamics of Nipah virus in Bangladesh, highlighting key risk areas.

Key Points

  • The study aims to investigate the evolutionary and geographic dynamics of Nipah virus strains in Bangladesh to enhance outbreak management.
  • Conducted phylodynamic and geographic analyses using nucleoprotein gene sequences from human and bat samples.
  • Incorporated publicly available NiV genomes up through November 2024.
  • Applied Bayesian evolutionary analysis to spatiotemporal data of the virus.
  • Identified two major lineages of Bangladeshi NiV: BD-1 and BD-2, with the latter containing most bat-derived sequences as of 2023.
  • Estimated evolutionary rate of NiV in Bangladesh at 4.89 × 10⁻⁴ substitutions/site/year.
  • Revealed geographic clusters of NiV strains ranging from 6.54 km to 116.09 km, indicating ongoing evolution and expansion.

Cite This Study

Rahman et al. (2026) studied this question.

synapsesocial.com/papers/69b4fbf9b39f7826a300c8f2https://doi.org/10.1128/spectrum.02319-25
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