Research reveals that RNA polymerase II is targeted by over 100 protein kinases, suggesting new mechanisms of epigenetic regulation.
Abstract How genes respond to external signals is poorly understood, with transcription factors and histones proposed as mediators of signals to RNA polymerase II (Pol II). However, recent work shows that Pol II is the direct target of more than 100 protein kinases, a previously underappreciated mechanism for generating epigenetic complexity.
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Henikoff et al. (2026) studied this question.
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