PulseExploreJournal ClubDebatesTrendingResearchersJournals
Instagram
HomeExploreJournal ClubTrending
Synapse
⌘+K
Synapse
March 14, 2026Nature0 citationsOpen Access

Profiling Heterogeneity in Supratentorial Ependymomas Using Multi-dimensional Approaches

Multidimensional profiling of heterogeneity in supratentorial ependymomas

View Full Paper

Authors

DJDaeun JeongBroad InstituteSDSara G. DanielliBroad InstituteKMKendra K. MaaßGerman Cancer Research Center

Discussion

Loading...

Member takes

Overview

This research defines cellular states and organization in supratentorial ependymomas, indicating developmental insights and clinical implications.

Key Points

  • The aim is to explore the molecular and cellular heterogeneity of supratentorial ependymomas and their developmental roots.
  • Integrated single-cell and spatial transcriptomics
  • In vitro and in vivo live-cell imaging
  • Characterization of cell states and spatial organization
  • Analysis of microenvironmental factors
  • Two distinct progenitor-like cell states were identified: neuroepithelial-like and embryonic-like.
  • Tumour subgroups exhibited various modes of spatial organization influenced by mesenchymal and hypoxia signatures.
  • Brain-resident cells were found to affect the cellular makeup of ependymomas, promoting neuronal-like cell characteristics.
Ask AI
Helpful
Bookmark
Share
View Full Paper

Cite This Study

Jeong et al. (2026) studied this question.

synapsesocial.com/papers/69b4fc1fb39f7826a300cd22https://doi.org/10.1038/s41586-026-10214-2
Ask AI
Helpful
Bookmark
Share
View Full Paper

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Single-cell multidimensional profiling of tumor cell heterogeneity in supratentorial ependymomas2024
  2. 2EPEN-09. Single-cell multidimensional profiling of tumor cell heterogeneity in supratentorial ependymomas2025
  3. 3Single-nucleus transcriptomics of spinal ependymoma subtypes recognizes intratumoral heterogeneity2025
  4. 4Histopathological Assessment of Cellular Heterogeneity in Pediatric Ependymomas2025
  5. 5P01.15.A SINGLE NUCLEUS TRANSCRIPTOMICS OF SPINAL EPENDYMOMA TYPES AND SUBTYPES RECOGNIZES INTRATUMORAL HETEROGENEITY2025