Electrophotochemical process achieves C−H fluoroalkylation in heteroarenes, suggesting effective biomolecule modification.
C−H fluoroalkylation of heteroarenes and biomolecules employing inexpensive carboxylic acids based on electrophotochemical oxidation on a Fe2O3 photoanode was developed. Notably, the devised approach proved amenable to a wide range of versatile late-stage C−H fluoroalkylations of biorelevant heterocycles. Mechanistic studies supported a direct electron transfer to form a fluoroalkyl radical with a cost-efficient heterogeneous iron catalyst.
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Motornov et al. (2026) studied this question.
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