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March 14, 2026Cancer ResearchOpen Access

Mitochondrial-Localized Keratin 17 Promotes Chemoresistance in Basal-Like Pancreatic Cancer

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Authors

CPChun-Hao PanYLYinghuan LyuMGMonisankar Ghosh

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Overview

This research demonstrates how mitochondrial keratin 17 promotes chemoresistance in basal-like pancreatic cancer, suggesting a potential therapeutic target.

Key Points

  • The aim is to understand how keratin 17 influences chemoresistance in basal-like pancreatic cancer.
  • Identified mitochondrial localization of keratin 17 in basal-like pancreatic cancer cells.
  • Investigated the interaction between keratin 17 and dihydroorotate dehydrogenase.
  • Conducted pharmacologic inhibition studies in mouse models of pancreatic cancer.
  • Keratin 17 localizes to mitochondria and stabilizes dihydroorotate dehydrogenase.
  • Blocking keratin 17 entry into mitochondria sensitizes cells to gemcitabine treatment.
  • Combined treatment of gemcitabine and DHODH inhibition significantly reduced tumor growth and improved survival in mice with K17 positive tumors.

Cite This Study

Pan et al. (2026) studied this question.

synapsesocial.com/papers/69b4fc33b39f7826a300ce29https://doi.org/10.1158/0008-5472.can-25-4534
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Abstract C031: Keratin 17 promotes pancreatic cancer chemoresistance through mitochondrial translocation and stabilization of dihydroorotate dehydrogenase (DHODH)2024
  2. 2Keratin 17 is a prognostic and predictive biomarker in pancreatic ductal adenocarcinoma2024 · 9 citations
  3. 3Disassembly of embryonic keratin filaments promotes pancreatic cancer metastases2024
  4. 4Keratin 17 modulates the immune topography of pancreatic cancer2024 · 4 citations
  5. 5Keratin 17 modulates the immune topography of pancreatic cancer2024