Mechanistic insights into mitigation of sepsis-induced acute lung injury by quercitrin via TLR4/MAPK pathway inhibition

Qian Sang; Chunhua Cai; Xiaoxiao Lu; Qinfu Xu; Mingqin Zhou; Chunya Lu

doi:10.1093/jpp/rgag018

February 27, 2026Journal of Pharmacy and Pharmacology

Mechanistic insights into mitigation of sepsis-induced acute lung injury by quercitrin via TLR4/MAPK pathway inhibition

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Key Points

To explore how quercitrin mitigates sepsis-induced acute lung injury through specific molecular pathways.
Investigated the effects of quercitrin on LPS-induced acute lung injury.
Analyzed inflammatory responses and oxidative stress levels.
Examined the TLR4/MAPK signaling pathway's role in quercitrin's protective mechanism.
Quercitrin significantly reduced inflammatory responses and oxidative stress in models of acute lung injury.
Inhibition of the TLR4/MAPK pathway was key to the protective effects observed.
The findings suggest quercitrin may be a viable therapeutic option for sepsis-related acute lung injury.

Implication

Quercitrin demonstrates protective effects against acute lung injury in sepsis, indicating its therapeutic potential.

Abstract

Quercitrin protects against LPS-induced ALI by mitigating inflammatory responses and oxidative stress. This protection is mechanistically linked to the inhibition of the TLR4/MAPK signaling pathway, underscoring its therapeutic potential for sepsis-associated ALI.

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Cite This Study

Sang et al. (2026) studied this question.

synapsesocial.com/papers/69b4fc44b39f7826a300d021 https://doi.org/10.1093/jpp/rgag018

View Full Paper

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Mechanistic insights into mitigation of sepsis-induced acute lung injury by quercitrin via TLR4/MAPK pathway inhibition

Key Points

Implication

Abstract

Discussion

Cite This Study

Mechanistic insights into mitigation of sepsis-induced acute lung injury by quercitrin via TLR4/MAPK pathway inhibition

Key Points

Implication

Abstract

Discussion

Cite This Study

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