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September 10, 2025Food Science & NutritionOpen Access

Quercetin Improves Lipopolysaccharide‐Induced Septic Liver Injury by Inhibiting the Activation of ROCK/NF‐κB/NLRP3 Pathway

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Authors

LXLiying XiaoLKLingya KongMHMing Han

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Overview

Experimental analysis revealed quercetin improves liver function in septic rats, suggesting a role in inflammation reduction through the ROCK/NLRP3 pathway.

Key Points

  • Quercetin significantly reduced liver injury markers in septic liver injury models, improving overall liver function.
  • Specific measurements showed decreased levels of ALT and AST, indicating restored liver health in treated rats.
  • Histopathological evaluations confirmed that quercetin mitigated liver lesions and oxidative stress caused by lipopolysaccharide exposure.
  • The mechanism suggests quercetin's ability to inhibit the ROCK/NLRP3 pathway plays a crucial role in reducing inflammation and oxidative stress.

Cite This Study

Xiao et al. (2025) studied this question.

synapsesocial.com/papers/68c1b1a154b1d3bfb60e94e4https://doi.org/10.1002/fsn3.70757
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Also Consider

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  1. 1Quercetin attenuates lipopolysaccharide-induced hepatic inflammation by modulating autophagy and necroptosis2024 · 11 citations
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  5. 5Comparative Effects of Quercetin and its α- and β-D-glucoside Derivatives in LPS-Stimulated C6 Astroglial Cells2026