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September 20, 2025Applied Biological ChemistryOpen Access

Quercetin alleviates LPS-induced embryonic lung fibroblast injury by regulating METTL3/TBL1XR1 expression

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Authors

YDYufeng DouYJYang JiaoNHNa Huang

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Overview

This study shows quercetin mitigates LPS-induced embryonic lung fibroblast damage, indicating METTL3 and TBL1XR1 play critical roles.

Key Points

  • Quercetin significantly alleviates embryonic lung fibroblast injury induced by LPS.
  • TBL1XR1 and METTL3 were both found to be elevated in lung injury tissues, reduced by quercetin treatment.
  • Methyltransferase 3 (METTL3) acts on m6A methylation to stabilize TBL1XR1 mRNA, impacting lung fibroblast viability.
  • Increasing TBL1XR1 levels countered the effects of METTL3 deficiency on lung injury, highlighting its protective role.

Cite This Study

Dou et al. (2025) studied this question.

synapsesocial.com/papers/68d46ab431b076d99fa67d43https://doi.org/10.1186/s13765-025-01036-3
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Quercetin attenuates lipopolysaccharide-induced hepatic inflammation by modulating autophagy and necroptosis2024 · 11 citations
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  3. 3Elucidating the protective role of quercetin against lipopolysaccharide-induced necroptosis in broiler thymus: insights from Nrf2/PERK signaling based on network pharmacology and experimental validation2026
  4. 4Quercetin ameliorates epithelial-mesenchymal transition and inflammation by targeting FSTL1 and modulating the NF-κB pathway in pulmonary fibrosis2025 · 12 citations
  5. 5Quercetin Alleviates Liver Fibrosis via Neutrophil Infiltration Mediated by Glycolysis of Liver Sinusoidal Endothelial Cells2024