Effect of Skeletal Muscle Mass Loss on Outcomes of Patients With Intraductal Papillary Mucinous Neoplasm

Soichiro Oda; Kazumichi Kawakubo; Ryo Takagi; Katsuma Nakajima; Shoya Shiratori; Hiroki Yonemura; Shunichiro Nozawa; Ryo Sugiura; Masatsugu Ohara; Masaki Kuwatani; Naoya Sakamoto

doi:10.1097/mpa.0000000000002628

March 12, 2026Pancreas

Effect of Skeletal Muscle Mass Loss on Outcomes of Patients With Intraductal Papillary Mucinous Neoplasm

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Key Points

This research examines how the loss of skeletal muscle mass affects patient outcomes in intraductal papillary mucinous neoplasm (IPMN).
Assessment of skeletal muscle mass in patients with IPMN.
Evaluation of all-cause mortality rates associated with muscle loss.
Analysis of the relationship between muscle mass and pancreatic cancer incidence.
Skeletal muscle mass loss is identified as an independent risk factor for increased all-cause mortality.
Patients with lower PMI (psoas muscle index) demonstrate a higher risk of developing pancreatic cancer.
Better outcomes are noted for patients with low comorbidities when undergoing long-term surveillance.

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Implication

This analysis reveals heightened pancreatic cancer risk in patients with skeletal muscle loss, suggesting the need for close monitoring.

Abstract

Skeletal muscle mass loss was an independent risk factor for all-cause mortality, and it might be associated with the risk factor for the incidence of pancreatic cancer, particularly IPMN-derived carcinoma in patients with IPMN. Patients with a low PMI and minimal comorbidities might be better to undergo long-term surveillance due to their increased risk of pancreatic cancer.

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Oda et al. (2026) studied this question.

synapsesocial.com/papers/69b4fc44b39f7826a300d127 https://doi.org/10.1097/mpa.0000000000002628

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Effect of Skeletal Muscle Mass Loss on Outcomes of Patients With Intraductal Papillary Mucinous Neoplasm

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Effect of Skeletal Muscle Mass Loss on Outcomes of Patients With Intraductal Papillary Mucinous Neoplasm

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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