What question did this study set out to answer?

This research aims to explore the role of NCOA4-mediated ferritinophagy in regulating ferroptosis in intestinal epithelial cells during colitis.

March 14, 2026Biology DirectOpen Access

NCOA4-mediated ferritinophagy modulates colitis-associated ferroptosis in intestinal epithelial cells and mucosal repair

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Authors

QHQiqi HuangNantong University LLLi Ling LiuCentral South University YZYue ZhaoHebei University of Technology

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Implication

Experiment investigates how NCOA4-mediated ferritinophagy affects ferroptosis in intestinal epithelial cells, suggesting therapeutic targets for colitis.

Key Points

This research aims to explore the role of NCOA4-mediated ferritinophagy in regulating ferroptosis in intestinal epithelial cells during colitis.
Used dextran sulfate sodium salt (DSS) to induce colitis in animal and NCM460 cell models.
Measured oxidative stress markers, including Fe2+, ROS, and MDA, in IECs.
Administered ferroptosis inhibitor liproxstatin-1 and autophagy inhibitor 3-MA to assess tissue damage.
Conducted NCOA4 knockdown and overexpression experiments to evaluate effects on ferritinophagy and ferroptosis.
DSS treatment significantly induced ferroptosis in IECs, increasing oxidative stress markers and decreasing GPX4.
Inhibitors improved colonic tissue damage and reduced mucosal permeability markers.
NCOA4 knockdown downregulated autophagy-related proteins and reduced ferroptosis, enhancing mucosal repair.
Overexpression of NCOA4 aggravated ferroptosis and intestinal damage.

Cite This Study

Huang et al. (2026) studied this question.

synapsesocial.com/papers/69b4fc44b39f7826a300d12f https://doi.org/10.1186/s13062-026-00747-x

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Implication

Experiment investigates how NCOA4-mediated ferritinophagy affects ferroptosis in intestinal epithelial cells, suggesting therapeutic targets for colitis.

NCOA4-mediated ferritinophagy modulates colitis-associated ferroptosis in intestinal epithelial cells and mucosal repair

Discussion

Member takes

Implication

Key Points

Cite This Study

NCOA4-mediated ferritinophagy modulates colitis-associated ferroptosis in intestinal epithelial cells and mucosal repair

Discussion

Member takes

Implication

Key Points

Cite This Study

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