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March 14, 2026Neuro-Oncology PediatricsOpen Access

STEM-06. OTX2 and LASR drive a pro-tumorigenic splicing program in Group 3 medulloblastoma

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Authors

JZJamie ZagozewskiOSOlivier SaulnierLLLisa Liang

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Overview

Uncovers how OTX2 and LASR influence splicing in Group 3 medulloblastoma, suggesting new treatment avenues.

Key Points

  • To investigate the role of OTX2 and LASR in regulating alternative splicing in Group 3 medulloblastoma.
  • Analyzed splicing alterations after silencing OTX2 in Group 3 MB cells.
  • Performed enhanced crosslinking and immunoprecipitation (eCLIP) to assess OTX2 binding mechanisms.
  • Utilized splice-blocking morpholinos to validate oncogenic and inhibitory splicing events.
  • Silencing OTX2 resulted in significant alterations in splicing events, predominantly involving alternatively spliced exons.
  • OTX2 and LASR proteins were found to regulate common differentially spliced genes.
  • Findings highlighted OTX2's indirect control over LASR complex binding influencing splicing outcomes.

Cite This Study

Zagozewski et al. (2025) studied this question.

synapsesocial.com/papers/69b4fc59b39f7826a300d1behttps://doi.org/10.1093/neuped/wuaf001.309
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