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Comprehensive analysis shows downregulated lysyl oxidase predicts brain metastasis risk in lung adenocarcinoma, suggesting potential for early intervention.
Our study establishes plasma EV-derived LOX as a promising non-invasive biomarker for LUAD-BrM through a comprehensive multi-omics validation strategy. We propose a model wherein downregulation of LOX, potentially driven by PI3K/AKT signaling in tumor-associated fibroblasts, contributes to ECM degradation and may promote brain-tropic metastasis. This finding offers new insights for risk stratification and timely intervention in LUAD patients.
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Li et al. (2026) studied this question.
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