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March 15, 2026Clinical RheumatologyOpen Access

Clinical characteristics and diagnostic indicators of childhood-onset systemic lupus erythematosus complicated with macrophage activation syndrome

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Authors

XCXin ChenHospital of Hebei Province JFJunchen FangHospital of Hebei Province PHPeitong HanHospital of Hebei Province

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Implication

Analysis reveals macrophage activation syndrome alters serum indicators in childhood-onset systemic lupus erythematosus, suggesting refined classification improves diagnosis.

Key Points

Evaluate clinical and laboratory characteristics of childhood-onset systemic lupus erythematosus complicated by macrophage activation syndrome.
Retrospective analysis of clinical laboratory data from 32 children with cSLE-MAS and 32 children with cSLE.
Comparison of clinical indicators, laboratory results, and diagnostic criteria applicability.
ROC curve analysis to determine optimal cutoff values for laboratory indicators.
cSLE-MAS showed higher liver dysfunction and hematologic abnormalities compared to cSLE.
Optimal cutoff values for diagnosis included ferritin ≥ 621.6 µg/L and aspartate aminotransferase ≥ 75.5 U/L.
Refining classification criteria increased sensitivity to 93.8% and specificity to 96.9%.

Cite This Study

Chen et al. (2026) studied this question.

synapsesocial.com/papers/69b5ff3b83145bc643d1b658 https://doi.org/10.1007/s10067-026-08010-4

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Implication

Analysis reveals macrophage activation syndrome alters serum indicators in childhood-onset systemic lupus erythematosus, suggesting refined classification improves diagnosis.

Clinical characteristics and diagnostic indicators of childhood-onset systemic lupus erythematosus complicated with macrophage activation syndrome

Discussion

Member takes

Implication

Key Points

Cite This Study

Clinical characteristics and diagnostic indicators of childhood-onset systemic lupus erythematosus complicated with macrophage activation syndrome

Discussion

Member takes

Implication

Key Points

Cite This Study

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