Systematic review shows dexamethasone induces muscle atrophy in C2C12 cells, indicating its efficacy for modeling skeletal muscle pathology.
The striking consistency of these findings suggests dexamethasone treatment of C2C12 myotubes is a reliable method of mimicking many features common to skeletal muscle pathology. This review provides insight into the use and expected outcomes of the dexamethasone-mediated model of atrophy in C2C12 myotubes and may serve as a helpful reference for future experiments utilizing this model.
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Klein et al. (2026) studied this question.
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