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March 15, 2026Regional Anesthesia & Pain Medicine

Prospective, non-inferiority, multicenter, randomized, single-blind clinical trial comparing cooled radiofrequency ablation to standard radiofrequency ablation to manage chronic facetogenic lumbar back pain

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Authors

DPDavid A ProvenzanoSLSean LiTDTimothy Deer

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Overview

Randomized trial found both cooled and standard radiofrequency ablation reduce pain in patients, suggesting effective management options for chronic facetogenic low back pain.

Key Points

  • To compare the effectiveness of cooled radiofrequency ablation (CRFA) versus standard radiofrequency ablation (SRFA) in managing chronic facetogenic lumbar back pain.
  • Conducted a multicenter, randomized, single-blind clinical trial
  • Patients with lumbar facetogenic pain received either CRFA or SRFA based on medial branch block results
  • Primary endpoint measured ≥50% pain relief on Numeric Rating Scale at 6 months
  • 74 patients randomized, with 61 completing the primary endpoint assessment
  • Both treatments significantly reduced pain scores, with CRFA showing non-inferiority to SRFA
  • Similar improvements observed in quality of life measures like SF-36 and Oswestry Disability Index

Cite This Study

Provenzano et al. (2026) studied this question.

synapsesocial.com/papers/69b5ff5c83145bc643d1bb58https://doi.org/10.1136/rapm-2025-107299
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Abstract No. 273 Cooled versus Standard Radiofrequency Ablation of the Medial Branch Nerves in the Management of Chronic Facetogenic Low Back Pain2024
  2. 2Outcomes of Thermal Radiofrequency Ablation of Lumbar Medial Branches as Treatment for Chronic Low Back Pain2026 · 1 citations
  3. 3Comparative Outcomes and Safety of Radiofrequency Ablation and Cryoablation for Lumbar Facet Joint Degeneration: A Single-Center Retrospective Cohort Study with 24-Month Follow-Up2025
  4. 4Effectiveness of thermal radiofrequency ablation versus corticosteroid injections for pain reduction in facet-mediated chronic low back pain: a systematic review and meta-analysis2026
  5. 5A Comparative Study of Radiofrequency Ablation and Steroid Injection Therapy for Lumbar Facet Joint Pain: Clinical Efficacy and Outcomes2026