Experimental results demonstrate efficient synthesis of APIs savolitinib and baxdrostat using nickel-catalyzed continuous flow methodology, suggesting a sustainable alternative in chemical processes.
Exploiting continuous flow for optimising Ni-catalyzed Suzuki–Miyaura reactions; a versatile, sustainable methodology translated directly to the synthesis of complex APIs savolitinib and baxdrostat.
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Bradbury et al. (2026) studied this question.
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