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March 15, 2026BiomedicinesOpen Access

Protective Antioxidant Effects of Ganoderma lucidum Against Prenatal Chlorpyrifos-Induced Developmental Nephrotoxicity in Rats

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Authors

ŞKŞeyma ŞİMŞİRGİL KARASinop UniversityDSDilek SağırSinop University

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Implication

Demonstrates protective effects of Ganoderma lucidum on renal injury from prenatal chlorpyrifos exposure in rats, suggesting potential therapeutic interventions.

Key Points

  • The objective is to evaluate the protective effects of Ganoderma lucidum against chlorpyrifos-induced nephrotoxicity in rat offspring.
  • Pregnant rats were administered CPF and/or GNL orally during gestation.
  • Biochemical, histopathological, immunohistochemical, and stereological analyses were performed on offspring's kidney tissues.
  • Blood samples were collected to measure serum urea and oxidative stress markers.
  • Prenatal CPF exposure increased serum urea and oxidative stress markers such as malondialdehyde and nitric oxide.
  • GNL co-treatment reduced oxidative stress and inflammatory cytokines, indicating protective effects.
  • Histopathological analysis revealed that GNL preserved renal structure and mitigated tubular injury.

Cite This Study

KARA et al. (2026) studied this question.

synapsesocial.com/papers/69b5ff8d83145bc643d1c449https://doi.org/10.3390/biomedicines14030658
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