Evaluation finds bilateral cardiac sympathetic denervation resolves syncope in inherited arrhythmias, suggesting a safe intervention with mild adverse effects.
Background Bilateral cardiac sympathetic denervation (BCSD) is infrequently used for long QT syndrome (LQTS) and catecholaminergic polymorphic ventricular tachycardia (CPVT), and its efficacy remains uncertain. Method We evaluated BCSD outcomes in these patients. Result Among three CPVT cases, none experienced preoperative syncope, fatal events, or appropriate ICD shocks after BCSD. In LQTS, syncope resolved in the LQT2/5 and LQT3 cases; the LQT3 patient with fetal‐onset ventricular fibrillation was discharged after mexiletine infusion, ICD implantation, and BCSD. Conclusion BCSD yielded meaningful only mild adverse effects in both CPVT and LQTS.
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Aoki et al. (2026) studied this question.
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