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March 15, 2026Clinical Microbiology Reviews

Current opinion on the potential role of liposomal amphotericin B in underexplored clinical scenarios

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Authors

JAJacopo AngeliniSFSara FerinLMLuca Martini

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Overview

Current opinion highlights liposomal amphotericin B's potential for invasive fungal infections, suggesting it may overcome limitations of standard therapies.

Key Points

  • To explore the potential role of liposomal amphotericin B in challenging clinical scenarios involving invasive fungal infections.
  • Discussion on the limitations of conventional antifungals, including echinocandins and azoles.
  • Analysis of liposomal amphotericin B's advantages in high-risk patient populations.
  • Consideration of L-AmB's safety profile and efficacy in various infections.
  • Liposomal amphotericin B offers a favorable alternative for treating infections like mucormycosis and leishmaniasis.
  • The potential applications of L-AmB in candidemia and biofilm-related infections are underexplored.
  • Clinical evidence supporting the use of L-AmB remains limited, but it may address issues of nephrotoxicity and drug interactions.

Cite This Study

Angelini et al. (2026) studied this question.

synapsesocial.com/papers/69b6068883145bc643d1c7achttps://doi.org/10.1128/cmr.00228-25
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Amphotericin B in the Era of New Antifungals: Where Will It Stand?2024 · 17 citations
  2. 2Potential lipid-based strategies of amphotericin B designed for oral administration in clinical application2023 · 18 citations
  3. 3[Multidisciplinary expert consensus on the clinical rational application of different formulations of amphotericin B (2024 edition)].2024 · 4 citations
  4. 4Real-World Efficacy and Safety of Liposomal Amphotericin B for Invasive Fungal Disease in Patients with Hematologic Malignancies: A Multicenter Retrospective Study2026
  5. 5Lipid-based amphotericin B formulations (ABCD/L-AmB) were associated with better outcomes than deoxycholate (AmB-d) in non-HIV-associated cryptococcal meningitis: A retrospective cohort study2026