Observational study reveals worsening joint symptoms and depression in women with acromegaly, indicating treatment impacts quality of life.
Female sex and prior radiotherapy emerged as predictors of progressive joint symptom worsening. Changes in depression and joint complaints alongside disease course suggest a complex involvement of IGF1. Dopamine agonists may negatively affect mood, though further studies are needed. Overall, joint disease had a greater and independent negative impact on QoL compared to mood disorder. Articular and psychological complications remain a significant burden, particularly in women with acromegaly.
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Cangiano et al. (2026) studied this question.
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