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To clarify the radical/non-radical dichotomy of reactive oxygen species for targeted therapeutic strategies in health and disease.

March 15, 2026Molecular BiomedicineOpen Access

Reactive oxygen species in health and disease

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To clarify the radical/non-radical dichotomy of reactive oxygen species for targeted therapeutic strategies in health and disease.
Organizing ROS sources and neutralizing systems along a radical versus non-radical axis
Evaluating the spatial and kinetic behaviors of different ROS types
Highlighting hybrid ROS-targeting strategies
Low-dose radicals enhance stress resilience and metabolic adaptation
Non-radical ROS regulate physiological plasticity
Radical therapies provide cytotoxicity in disease treatment
Therapeutic applications leverage synchronized delivery of both radical and non-radical ROS

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Review highlights therapeutic strategies utilizing radical and non-radical reactive oxygen species in disease management and health.

Ren et al. (2026) studied this question.

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