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Framework evaluates uncontrolled trials in tuberculosis, indicating phase 3 trials are unjustified and unethical.
Tuberculosis treatment trials have used various comparison strategies. To inform trial design for novel tuberculosis regimens, we applied an existing framework for evaluating when uncontrolled trials might be justified. We conclude that the conditions are not met for tuberculosis treatment and that uncontrolled phase 3 trials should not be performed.
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McKenna et al. (2026) studied this question.
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