Computational study of ACE and AGT gene of RAAS pathway

Renin angiotensin aldosterone system (RAAS) is a hormone regulatory hormone system that regulate blood pressure. The two major genes ACE and AGT are the players of RAAS pathway. These genes codes for angiotensin convertase enzyme and angiotensinogen protein, respectively. The angiotensin convertase enzyme converts inactive angiotensinogen into active angiotensin which further helps in the regulation of blood pressure. Due to an imbalance in this pathway it may cause hypertension. So in the present study we decided to perform the computational study of ACE and AGT genes. We evaluated the deleterious/damaging effect of SNPs of ACE and AGT genes by SIFT and I-Mutant 2.0. The total number of SNPs predicted to be deleterious by both tools and were 5 (1.83%) and 22 (6.07%) for AGT and ACE genes, respectively. We also studied subcellular location of ACE and AGT genes and drugs targeting these genes from database GeneCards. Further, the result output of both the softwares was also compared.