Association between arsenic exposure and the risk of Alzheimer's disease: A cohort study in Sweden

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Cohort study identifies dose-response association of arsenic exposure with increased Alzheimer's disease risk in young adulthood.

To investigate the link between arsenic exposure and the risk of Alzheimer's disease across different levels.
Population-based cohort study with 1,549,700 individuals born in Sweden (1932-1950)
Follow-up period from 1970 to 2016
Classified individuals by groundwater arsenic levels from Geological Survey of Sweden
Diagnosed Alzheimers disease evaluated through Swedish National Patient Register
Association assessed using Cox models for various arsenic exposure levels.
2.7% of individuals exposed to high arsenic (>10 µg/l) showed elevated AD risk
Individuals born in high arsenic areas had 156% higher risk of AD
Similar patterns noted for young adulthood arsenic exposure
Dose-response relationships observed across arsenic exposure strata

Wei et al. (2026) studied this question.

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