Fibromuscular dysplasia and female sex were independently associated with lower quality of life scores in SCAD survivors, with a mean EQ-5D index score of 0.776.
Survivors of spontaneous coronary artery dissection experience significantly impaired health-related quality of life at 30 days, with female sex and comorbid fibromuscular dysplasia acting as independent predictors of worse outcomes.
MethodThis is a multicentre, prospective cohort study in 23 hospitals across Australia and New Zealand.Patients aged 18 years diagnosed with SCAD confirmed on core laboratory adjudication were recruited and gave their informed consent.HRQoL was measured using the European Quality-of-Life 5 Dimensions (EQ-5D) questionnaire at 30 days after the index SCAD event.Beta-regression model was used to explore determinants of HRQoL. ResultsFrom 2021 to 2025, 193 people with confirmed SCAD were prospectively recruited, with mean age 52.7610.7 years, 89.1% female, mean body mass index 28.266.2kg/m 2 , and 82.4% White.At least one cardiovascular risk factor was present in 50.8%, with hypertension the most common (30.1%).At a median of 33 days from the index SCAD event, the mean EQ-5D index summary score was 0.7760.19and the mean EQ-5D visual analogue scale score was 68.5617.1.Overall, 43.0% had at least moderate pain/discomfort and 57.0% had at least moderate anxiety or depression.On multivariable analysis, fibromuscular dysplasia (FMD, coefficient -0.25; p=0.005), and female sex (coefficient 20.35; p=0.04) were independently associated with lower QoL scores. ConclusionsSCAD has a significant impact on the HRQoL of survivors with high rates of pain, anxiety, and depression.Female sex and an FMD diagnosis were independent predictors of lower HRQoL.These findings support the need for FMD and mental health screening and support in SCAD survivors.
Dang et al. (2026) studied this question. Fibromuscular dysplasia and female sex were independently associated with lower quality of life scores in SCAD survivors, with a mean EQ-5D index score of 0.776.