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March 15, 2026Molecular & Cellular ProteomicsOpen Access

Glycoinformatic profiling of label-free intact heparan sulfate oligosaccharides

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Authors

MMMarissa L. Maciej-HulmeRadboud University NijmegenJKJandi KimERElijah T. RobertsUniversity of Georgia

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Implication

Profiled heparan sulfate oligosaccharides in kidney disease patients, indicating potential for clinical diagnostics.

Key Points

  • This research aims to develop a mass spectrometry-based approach to profile heparan sulfate oligosaccharides for potential clinical applications.
  • Utilized mass spectrometry to analyze native heparan sulfate oligosaccharides from healthy human plasmas.
  • Developed a glycoprofiling method that retains structural complexity.
  • Created an HS index (Heparan-ome) for individual patients.
  • Evaluated plasma samples from kidney disease patients.
  • Identified a distinct subset of 21% within membranous glomerulopathy patients.
  • Highlighted variances in heparan sulfate profiles among different patient groups.
  • Demonstrated the utility of HS glycoprofiling for future clinical diagnostics.

Cite This Study

Maciej-Hulme et al. (2026) studied this question.

synapsesocial.com/papers/69b64c67b42794e3e660db47https://doi.org/10.1016/j.mcpro.2026.101553
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