De novo recovery of Ghana virus, an African bat Henipavirus, reveals differential tropism and attenuated pathogenicity compared to Nipah virus

Key Points

• This research investigates the characteristics and pathogenic potential of Ghana virus, comparing it to Nipah virus.
• Isolated Ghana virus from African bats.
• Conducted comparative analyses of tropism and pathogenicity.
• Examined viral behavior in vitro and in vivo models.
• Ghana virus exhibits differential tropism compared to Nipah virus.
• Pathogenicity of Ghana virus is significantly attenuated.
• Findings suggest unique behavioral aspects of Ghana virus in its natural hosts.