A Comparison of Endodontic Microbiomes Associated With Symptomatic and Asymptomatic Apical Periodontitis by Next‐Generation Sequencing

David Donnermeyer; Edgar Schäfer; Daniel Hagenfeld; Benjamin Ehmke; Karola Prior; Dag Harmsen; Madgalena Ibing; Sebastian Bürklein; Thomas Gerhard Wolf; Johannes Matern

doi:10.1111/iej.70140

March 13, 2026International Endodontic JournalOpen Access

A Comparison of Endodontic Microbiomes Associated With Symptomatic and Asymptomatic Apical Periodontitis by Next‐Generation Sequencing

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Key Points

This research aims to compare the microbiomes associated with symptomatic and asymptomatic apical periodontitis.
Utilized next-generation sequencing to analyze microbial communities
Compared microbiomes from symptomatic and asymptomatic cases
Assessed relative abundance of various microorganisms
No specific microorganisms were linked to symptomatic expression
Identified shifts in microbial community abundance as a key factor

Implication

Comparison reveals shifts in microbial community abundance in endodontic conditions, suggesting no specific pathogens.

Abstract

The expression of clinical symptoms in apical periodontitis does not appear to be determined by specific microorganisms but may instead reflect shifts of the relative abundance of the microbial community.

Discussion

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Cite This Study

Donnermeyer et al. (2026) studied this question.

synapsesocial.com/papers/69b64d5cb42794e3e660e40e https://doi.org/10.1111/iej.70140

View Full Paper

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A Comparison of Endodontic Microbiomes Associated With Symptomatic and Asymptomatic Apical Periodontitis by Next‐Generation Sequencing

Key Points

Implication

Abstract

Discussion

Cite This Study

A Comparison of Endodontic Microbiomes Associated With Symptomatic and Asymptomatic Apical Periodontitis by Next‐Generation Sequencing

Key Points

Implication

Abstract

Discussion

Cite This Study

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