⌘+K

Pulse Explore Clubs Researchers Journals

Home Clubs Explore

March 12, 2026Frontiers in Cell and Developmental BiologyOpen Access

Editorial: Cellular and molecular pathologies of Alzheimer’s disease: understanding the link between different etiological factors for therapeutic exploitation

Mohammad Golam Sabbir

View Full Paper

Ask AI

Bookmark

Share

Key Points

The editorial explores the cellular and molecular mechanisms underlying Alzheimer’s disease (AD) pathologies and their therapeutic implications.
Literature review of recent findings on tau, CAMKK2, TREM2, and autophagy in AD mechanisms.
Analyzed gene expression, protein interactions, and biochemical pathways associated with AD progression.
Discussed potential biomarkers and therapeutic strategies for targeting epigenetic and proteostatic pathways.
Identified nuclear tau as a modulator of transcription in early AD stages.
Associated CAMKK2 with calcium signaling and iron handling disruptions in AD.
Highlighted the dual role of TREM2 in regulating tau pathologies at different disease stages.

Implication

Editorial summarizes mechanisms linking various factors to Alzheimer’s disease pathologies, implying therapeutic avenues.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Mohammad Golam Sabbir (2026) studied this question.

synapsesocial.com/papers/69b79d538166e15b153aac20 https://doi.org/10.3389/fcell.2026.1813923

View Full Paper

Ask AI

Bookmark

Share

Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Microglial checkpoint collapse in Alzheimer’s disease: a tri-axial framework for biomarker-informed neuroimmune therapyOriginal Research · 2026
2The Role of Microglial Cells and Cytokine Modulation in Alzheimer’sDisease: A Neuroinflammatory PerspectiveReview · 2026 · 3 citations
3Interplay of TREM2 and APOE in Alzheimer’s disease: mechanisms, imaging biomarkers, and therapeutic opportunitiesReview · 2026
4Emerging pathological mechanisms of Alzheimer’s disease pathogenesis: from neuroimmune interactions to intercellular communicationOriginal Research · 2026 · 1 citations
5Precision Neurodegeneration: Integrating Molecular Mechanisms, Biomarkers, and Targeted TherapeuticsEarly-Phase Clinical Trial · 2026 · 1 citations