What question did this study set out to answer?

The aim is to assess antimicrobial resistance trends and characterize carbapenemase-producing Enterobacterales in companion animals.

March 16, 2026Veterinary MicrobiologyOpen Access

Monitoring antimicrobial resistance trends and emerging carbapenemases in Enterobacterales causing companion animal infections: a four-year study

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Longitudinal analysis reveals antimicrobial resistance trends and carbapenemases in companion animals, suggesting vital health implications.

The aim is to assess antimicrobial resistance trends and characterize carbapenemase-producing Enterobacterales in companion animals.
Conducted longitudinal trend analysis of Enterobacterales isolates from clinical samples.
Performed antimicrobial susceptibility testing using disk diffusion on various antibiotic classes.
Identified potential CPE using selective agar, confirmed via multiplex PCR and characterized through whole-genome sequencing.
Analyzed strain clonality through maximum likelihood phylogenetic trees and pairwise SNP comparisons.
Klebsiella spp. and Enterobacter spp. were significantly more likely to show antimicrobial resistance compared to E. coli.
Most AMR phenotypes remained stable or declined, though an increase in fluoroquinolone resistance was noted.
Eighteen CPE strains linked to high-risk global STs were detected, including E. coli ST410.
Genomic analysis revealed possible recent clonal transmission among strains from different sources.

Fernandes et al. (2026) studied this question.

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Longitudinal analysis reveals antimicrobial resistance trends and carbapenemases in companion animals, suggesting vital health implications.