Apolipoprotein A-IV Cardiac Amyloidosis Diagnosed by Mass Spectrometry–Based Proteomic Analysis

Key Points

• This research aims to differentiate apolipoprotein A-IV cardiac amyloidosis from ATTR CA using proteomic analysis.
• Utilized mass spectrometry-based proteomic analysis to investigate cardiac amyloidosis
• Examined histopathologic findings to distinguish between AApoA-IV and ATTR amyloidosis
• Assessed patient cases involving elderly-onset heart failure with preserved ejection fraction.
• Mass spectrometry revealed distinct proteomic profiles for apolipoprotein A-IV cardiac amyloidosis
• Characteristic histopathologic findings allow differentiation from ATTR cardiac amyloidosis.
• Positive uptake on bone scintigraphy was noted in cases of apolipoprotein A-IV cardiac amyloidosis.