Apolipoprotein A-IV Cardiac Amyloidosis Diagnosed by Mass Spectrometry–Based Proteomic Analysis

Q: What does this research mean for the field?

Mass spectrometry-based proteomic analysis can differentiate Apolipoprotein A-IV cardiac amyloidosis from ATTR cardiac amyloidosis. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

Yu Masutani; Kenji Onoue; Tsunenari Soeda; Tomoya Nakano; Yasuhiro Sakaguchi; Jin Endo; Yukako Shintani-Domoto; Hiromitsu Kanamori; Fuyuki Kametani; Shungo Hikoso; Hiroyuki Kawata

doi:10.1016/j.jaccas.2026.107355

March 1, 2026JACC Case ReportsOpen Access

Apolipoprotein A-IV Cardiac Amyloidosis Diagnosed by Mass Spectrometry–Based Proteomic Analysis

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Key Points

This research aims to differentiate apolipoprotein A-IV cardiac amyloidosis from ATTR CA using proteomic analysis.
Utilized mass spectrometry-based proteomic analysis to investigate cardiac amyloidosis
Examined histopathologic findings to distinguish between AApoA-IV and ATTR amyloidosis
Assessed patient cases involving elderly-onset heart failure with preserved ejection fraction.
Mass spectrometry revealed distinct proteomic profiles for apolipoprotein A-IV cardiac amyloidosis
Characteristic histopathologic findings allow differentiation from ATTR cardiac amyloidosis.
Positive uptake on bone scintigraphy was noted in cases of apolipoprotein A-IV cardiac amyloidosis.

Implication

Mass spectrometry identifies apolipoprotein A-IV cardiac amyloidosis in elderly patients, indicating critical diagnostic advancements.

Abstract

AApoA-IV CA typically presents with elderly-onset heart failure with preserved ejection fraction and may show positive uptake on bone scintigraphy. Differentiation from ATTR CA is possible based on characteristic histopathologic findings and mass spectrometry-based proteomic analysis.

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Cite This Study

Masutani et al. (2026) studied this question.

synapsesocial.com/papers/69b79e398166e15b153ab35f https://doi.org/10.1016/j.jaccas.2026.107355

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Apolipoprotein A-IV Cardiac Amyloidosis Diagnosed by Mass Spectrometry–Based Proteomic Analysis

Key Points

Implication

Abstract

Discussion

Cite This Study

Apolipoprotein A-IV Cardiac Amyloidosis Diagnosed by Mass Spectrometry–Based Proteomic Analysis

Key Points

Implication

Abstract

Discussion

Cite This Study

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