What question did this study set out to answer?

The study aims to assess the clinical relevance of the albumin-bilirubin score in alcohol-associated liver diseases, specifically hepatitis and cirrhosis.

March 16, 2026

The albumin–bilirubin score can reflect disease severity in alcohol-associated hepatitis and cirrhosis

Key Points

The study aims to assess the clinical relevance of the albumin-bilirubin score in alcohol-associated liver diseases, specifically hepatitis and cirrhosis.
Retrospective case control design
Included 51 patients with alcohol-associated hepatitis, 39 with cirrhosis, and 48 healthy controls
Calculated albumin-bilirubin score for all participants
Recorded Child-Pugh classification for cirrhosis patients and Maddrey’s Discriminant Function for hepatitis patients
Calculated MELD-Na score and Fibrosis-4 index for all participants.
Mean ALBI scores were highest in the alcohol-associated hepatitis patients
Mean ALBI scores were lowest in the healthy controls
Statistical significance was noted in the differences in ALBI scores among groups.

Abstract

Aims: The albumin-bilirubin (ALBI) score has been evaluated in various liver diseases, however its clinical relevance in alcoholassociated liver disease (ALD) remains unclear. This study aimed to evaluate whether the ALBI score reflects disease severity in patients with alcohol-associated hepatitis (AH) and alcohol-associated cirrhosis (AC).Methods: In this retrospective case control study, 51 AH patients, 39 AC patients, and 48 healthy controls (HCs) were included. The ALBI score was calculated for all participants. The Child-Pugh classification (CPC A-C) was recorded for AC, while Maddrey’s Discriminant Function (MDF) for AH. The Model for End-Stage Liver Disease Sodium (MELD-Na) score was calculated for both patient groups, and the Fibrosis-4 (FIB-4) index was calculated in all participants. Results: Mean ALBI scores were highest in the AH patients and the lowest in the HCs (p

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