Maternal separation disrupts emotional, cognitive, and metabolic development in rats: protective and regulatory effects of environmental enrichment

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The research aims to assess the impact of early-life maternal separation on growth and behavior and explore the protective role of environmental enrichment.
Allocated Sprague-Dawley litters to control, maternal separation (MS), or MS with environmental enrichment (MS+EE) groups.
Conducted daily 180-minute maternal separations from postnatal day 2-14.
Initiated environmental enrichment after postnatal day 14.
Monitored body weight at multiple developmental stages.
Performed neurobehavioral assessments using various tests including OFT, EPM, FST, and PAT.
Maternal separation led to reduced weight gain on postnatal day 7.
Environmental enrichment mitigated some neurobehavioral disruptions caused by maternal separation.
Sex-dependent differences in responses to maternal separation and enrichment were identified.

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Evaluates maternal separation's effects on development in rats, showing environmental enrichment offers protection.

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Ata et al. (2026) studied this question.

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