Explores TGFbeta1's effect on bone growth around implants in a rat model, suggesting improved outcomes with osteogenic factors.
Synthetic bone substitutes provide an alternative to autograft but do not give equivalent clinical results. Their performance may be enhanced by adding osteogenic growth factors. In this study, TGFbeta1 was absorbed on to a carrier of 0 tricalcium phosphate and Gelfoam(R) and used to fill a defect around a tibial implant in a rat model of revision arthoplasty.
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Clarke et al. (2004) studied this question.
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