Determining the Minimal Clinically Important Difference of the 40‐Item Smell Identification Test in People With Cystic Fibrosis

Eugene Oh; Jessa E Miller; Michelle J. Lee; Anna C. Zemke; David Baraghoshi; M. Strand; Jeremiah A. Alt; Todd Bodner; Michael Chang; Naweed I. Chowdhury; Patricia H. Eshaghian; Anne E. Getz; Jennifer L. Goralski; David A. Gudis; Peter H. Hwang; Ashoke Khanwalkar; Adam J. Kimple; Jivianne T. Lee; D. Li; Jess C. Mace; Jayakar V. Nayak; Jonathan B. Overdevest; Zara Patel; Daniella K. Safatian; Rodney J. Schlosser; Brent Senior; Amanda L. Stapleton; Timothy L. Smith; Zachary M. Soler; Jeffrey D. Suh; G. Turner; Marilene B. Wang; Milene T. Saavedra; Jennifer L. Taylor‐Cousar; D. Beswick

doi:10.1002/alr.70136

Key Points

To identify the minimal clinically important difference (MCID) for the 40-Item Smell Identification Test in individuals with cystic fibrosis.
Conducted the 40-Item Smell Identification Test for participants with cystic fibrosis.
Analyzed results to determine a meaningful change in olfactory function.
Developed disease-specific threshold for clinically relevant assessment.
Established a clinically interpretable cut-off score for the smell identification test.
Validated the significance of the new threshold for guiding clinical care and research.
Highlighted the need for disease-specific MCIDs in olfactory assessments.

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Implication

This research determines a critical threshold for olfaction in cystic fibrosis, suggesting its utility in clinical care and future studies.

Abstract

This CF-specific SIT threshold provides a clinically interpretable cut-off for assessing olfaction. These findings establish a foundation for future work and highlight the importance of developing disease-specific MCIDs to guide clinical care and research.

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Cite This Study

Oh et al. (2026) studied this question.

synapsesocial.com/papers/69b79e7c8166e15b153abe4f https://doi.org/10.1002/alr.70136

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Determining the Minimal Clinically Important Difference of the 40‐Item Smell Identification Test in People With Cystic Fibrosis

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Determining the Minimal Clinically Important Difference of the 40‐Item Smell Identification Test in People With Cystic Fibrosis

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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