Determining the Minimal Clinically Important Difference of the 40‐Item Smell Identification Test in People With Cystic Fibrosis

Key Points

• To identify the minimal clinically important difference (MCID) for the 40-Item Smell Identification Test in individuals with cystic fibrosis.
• Conducted the 40-Item Smell Identification Test for participants with cystic fibrosis.
• Analyzed results to determine a meaningful change in olfactory function.
• Developed disease-specific threshold for clinically relevant assessment.
• Established a clinically interpretable cut-off score for the smell identification test.
• Validated the significance of the new threshold for guiding clinical care and research.
• Highlighted the need for disease-specific MCIDs in olfactory assessments.

Abstract