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This review analyzes strategies to enhance the performance of collagen-based artificial corneas, indicating their potential as donor tissue substitutes.
Collagen-based artificial corneas are a promising regenerative alternative to scarce donor tissue. However, their clinical success is limited by mechanical weakness, enzymatic degradation, and poor bio-integration. This review provides a comprehensive analysis of the current state and the future strategies to optimize collagen for making pro-regenerative corneal implants, enhancing the performance, functionality, and clinical viability of the collagen-based artificial cornea as a substitute for donor tissue.
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Huang et al. (2026) studied this question.
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