Rationalization of Antimicrobial Use as a Strategy for Patient Safety and the Fight Against Microbial Resistance: Impact of Clinical Interventions Evaluated Between 2019 and 2024 in a Tertiary Hospital
Observational study evaluates the impact of clinical interventions on microbial resistance in a hospital setting, suggesting effective strategies for patient safety.
Key Points
The study aims to evaluate the effects of antimicrobial rationalization on patient safety and microbial resistance reduction.
Conducted an observational and retrospective analysis from January 2019 to December 2024.
Implemented daily evaluations of antimicrobial prescriptions with care team discussions.
Verified compliance with rational use recommendations.
Analyzed microbiological data to assess changes in resistance patterns.
Increased daily prescription evaluations by 25%.
Achieved a 26% reduction in overall antimicrobial use.
Notable reductions in bacterial resistance: 60% in carbapenem resistance, 18% in MRSA, and 28% in ESBL-producing Enterobacteriaceae.