Association Between Microscopic Hematuria and Proteinuria Remission in Adult Nephrotic Syndrome

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Microscopic hematuria at diagnosis is independently associated with a lower likelihood of achieving complete remission of proteinuria in adults with nephrotic syndrome. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

Ryuto Yoshida; Ryunosuke Mitsuno; Takashin Nakayama; Keita Hirano; Tomoaki Itoh; Dai Matsumoto; Ei Kusahana; Kenta Hoshi; Motoaki Komatsu; Yoichi Oshima; Shogo Iwabuchi; Kentaro Fujii; Yoshikazu Hara; Koji Futatsugi; Kyosei Nakamura; Takahisa Kawaguchi; Norifumi Yoshimoto; Aika Hagiwara; Akihito Hishikawa; Yasuyoshi Yamaji; Hirobumi Tokuyama; Marohito Murakami; Hiroto Matsuda; Chie Takimoto; Takashi Ando; Akinori Hashiguchi; Yuko Kaneko; Takashi Yokoo; Tatsuhiko Azegami; Kaori Hayashi

doi:10.1016/j.xkme.2026.101333

Key Points

To explore how microscopic hematuria correlates with proteinuria remission in adults with nephrotic syndrome.
Conducted a multicenter retrospective cohort study in Japan.
Included adults who underwent kidney biopsy for histological diagnoses.
Assessed microscopic hematuria through urine sediment examination at diagnosis.
Evaluated the association using log-rank and multivariable Cox regression analyses.
44% of patients had microscopic hematuria.
Lower remission rates in those with hematuria (P = 0.001).
Hazard ratio of 0.68 indicates lower likelihood of remission with hematuria.
Severity of hematuria negatively impacted remission rates.

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Implication

Multicenter cohort study examines the link between hematuria and proteinuria remission in adults with nephrotic syndrome, suggesting important prognostic value.

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Cite This Study

Yoshida et al. (2026) studied this question.

synapsesocial.com/papers/69b8ef12deb47d591b8c51b2 https://doi.org/10.1016/j.xkme.2026.101333

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Association Between Microscopic Hematuria and Proteinuria Remission in Adult Nephrotic Syndrome

Key Points

No abstract yet

Implication

Discussion

Cite This Study

Association Between Microscopic Hematuria and Proteinuria Remission in Adult Nephrotic Syndrome

Key Points

No abstract yet

Implication

Discussion

Cite This Study

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